Comment on “The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles”

paper
membrane traffic
neuroscience
Author

Granseth B, Odermatt B, Royle SJ, Lagnado L.

Doi

https://doi.org/10.1126/science.1175790

Citation

Granseth, B., Odermatt, B., Royle, S.J., and Lagnado, L. (2009). Comment on “The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles.” Science 325, 1499; author reply 1499.

Abstract

Zhang et al. (Research Articles, 13 March 2009, p. 1448) reported that synaptic vesicles usually release neurotransmitter through a kiss-and-run mechanism occurring within 1 second but that full collapse of the vesicles becomes more prevalent with repeated stimuli. We report that the kinetics of vesicle retrieval do not change during a stimulus train, with endocytosis occurring in 10 to 15 seconds.